The effect of exercise on metabolic crosstalk between heart and liver

Document Type : Review Articles

Authors

1 PhD Candidate of Exercise Physiology, Faculty of Sport Sciences, Islamic Azad University, Karaj, Iran

2 Department of Sport Sciences, Islamic Azad University, Urmia Branch, Urmia, Iran

Abstract

This research paper delves into the intricate interplay between the heart and liver within the realm of metabolic regulation, focusing on the impact of exercise as a pivotal modulator of this dynamic relationship. Through a comprehensive review of pertinent literature, encompassing peer-reviewed articles, reviews, and meta-analyses sourced from databases such as PubMed, Scopus, and Google Scholar, this paper analyzes the existing understanding of how exercise influences the metabolic crosstalk between the heart and liver. The findings underscore the positive influence of regular physical activity on the metabolic interplay between these vital organs, ultimately contributing to enhanced overall metabolic health. Emphasizing both physiological and molecular aspects, the review provides a succinct overview of its content, highlighting the significance of exercise in modulating metabolic processes. In exploring human studies, animal models, and molecular techniques, this review aims to not only consolidate current knowledge but also to identify research gaps, fostering a foundation for future investigations. The potential therapeutic implications of exercise in mitigating metabolic disorders through the modulation of heart-liver crosstalk are discussed. By addressing inclusion criteria such as studies published within the last decade, written in English, and focusing on human or animal models, this paper contributes to the evolving understanding of the intricate relationship between exercise, heart health, and liver function.

What is already known on this subject?

The existing knowledge on the subject of the effect of exercise on metabolic crosstalk between the heart and liver encompasses several key findings. It is known that exercise induces the release of various signaling molecules, including myokines from skeletal muscle and "exerkines" from the heart, liver, white and brown adipose tissue, and the nervous system. These molecules play a crucial role in inter-organ communication and contribute to the systemic effects of exercise on metabolism and overall health. Additionally, previous research has demonstrated that exercise can impact liver health by influencing liver enzymes, antioxidant systems, and metabolic pathways. Furthermore, the effects of different types of exercise, such as aerobic and resistance training, on cardiovascular risk factors and liver enzymes in various populations, including individuals with dyslipidemia and patients undergoing coronary interventions, have been investigated. This body of knowledge provides a foundation for understanding the complex interplay between exercise, the heart, and the liver, and its implications for metabolic health and disease prevention.

What this study adds?

This research adds to the existing knowledge by providing insights into the impact of exercise on liver enzymes and antioxidant systems, as well as the age-dependent effects of different exercise training regimens on genomic and metabolic remodeling in skeletal muscle and liver. It also contributes to understanding the effects of aerobic interval exercise on cardiovascular risk factors and liver enzymes in individuals with dyslipidemia. Furthermore, the study of a home-based exercise intervention's impact on cardiac biomarkers, liver enzymes, and cardiometabolic outcomes in patients after coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) provides valuable information on the potential benefits of exercise in a clinical setting (Bernier et al., 2022; Khan et al., 2019; Olgoye et al., 2021; Zolfaghari et al., 2020).

Keywords

Main Subjects

Acknowledgements

We thank the anonymous referees for their useful suggestion.

Funding

None.

Compliance with ethical standards

Conflict of interest No conflict of interest.

Ethical approval Not applicable.

Informed consent Not applicable.

Author contributions

Conceptualization: A.M; Methodology: A.M; Software: S.Z; Validation: A.M; Formal analysis: S.Z; Investigation: A.M; Resources: A.M; Data curation: S.Z; Writing - original draft: A.M; Writing - review & editing: A.M; Visualization: A.M; Supervision: A.M; Project administration: A.M; Funding acquisition: A.M.

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Journal of Exercise & Organ Cross Talk
Volume 3, Issue 4
December 2023
Pages 216-224

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History

  • Receive Date: 17 October 2023
  • Revise Date: 18 December 2023
  • Accept Date: 18 December 2023

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