Introduction: This study investigates the impact of concurrent training combined with fenugreek supplementation on myokines and lipid profiles in overweight and obese women, aiming to understand the potential beneficial effects of this intervention on related health markers.

Method and investigation: This study investigated the effects of concurrent training, fenugreek supplementation, and their combination on overweight women. Forty women with a BMI over 25 were randomly assigned to concurrent training, fenugreek supplementation, combined training/supplementation, or a control group. The training groups exercised three times a week for eight weeks, involving circular resistance training followed by aerobic activity. Supplement groups consumed fenugreek capsules twice daily. Blood samples were analyzed before and after the intervention to assess the impact of each intervention, employing t-tests and ANCOVA for statistical analysis.

Findings: Exercise training and supplementation, both individually and combined, significantly impact lipid profiles and myokines. Training, supplementation, and their combination led to decreased triglycerides (TG) and low-density lipoprotein (LDL) levels. Training and the combined intervention significantly increased high-density lipoprotein (HDL), irisin, and Myonectin, with supplementation alone also increasing HDL. The combined training and supplementation group demonstrated the most substantial positive effects on HDL, LDL, TG, irisin, and Myonectin compared to the other interventions.

Conclusion: Concurrent training, apart from fenugreek supplement consumption, can lead to increases in irisin and Myonectin secretion, whereas concurrent training, along with fenugreek consumption, can lead to favorable changes. Therefore, the use of concurrent training together with fenugreek training can be highly recommended for overweight people.