Journal of Eexercise & Organ Cross Talk

Synergistic effects of cinnamon supplementation and Tabata HIIT on metabolic health and performance outcomes in military cadets: Bridging traditional medicine and modern physiology

Document Type : Original Article

Authors

Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran

Abstract
The integration of herbal supplementation with exercise training may offer a novel hybrid strategy that bridges traditional medicine and modern performance science to enhance recovery and physical outcomes. This study aimed to evaluate the synergistic effects of cinnamon supplementation and Tabata-style high-intensity interval training (HIIT) on metabolic and performance outcomes in young male military cadets. Forty-eight healthy cadets were randomly assigned to four groups: Tabata training (T), cinnamon supplementation (S), Tabata + cinnamon (TS), and control (C). The intervention lasted six weeks, consisting of thrice-weekly Tabata sessions (87–100% HRmax) and daily oral cinnamon supplementation (1.5 g/day). Assessments conducted before and after the intervention included body composition, VO₂max, post-exercise blood lactate levels, and combat readiness scores based on the Army Combat Fitness Test. Statistical analysis employed paired t-tests and ANCOVA at a significance level of p < 0.05. Significant improvements were observed in the TS group compared to control: VO2max increased (p = 0.001), post-exercise lactate decreased (−1.93 mmol/L, p = 0.001), and combat readiness scores improved substantially (+63.6 points, p = 0.001). Comparable but less pronounced improvements were observed in the Tabata-only and cinnamon-only groups. No adverse effects were reported. The findings suggest that cinnamon—a time-honored medicinal spice—may potentiate the effects of high-intensity training by improving aerobic capacity, lactate clearance, and combat readiness. This study provides translational evidence supporting cinnamon as a safe, natural, and affordable traditional functional food that can enhance physical performance and metabolic resilience in tactical populations. The integration of traditional herbal supplementation with modern training paradigms offers a promising avenue in the evolving field of evidence-based traditional medicine.

What is already known on this subject?

• Cinnamon (Cinnamomum spp.) is a traditional medicinal spice with well-documented, antioxidant ,anti-inflammatory, and insulin-sensitizing properties.

• Previous studies have demonstrated the metabolic benefits of cinnamon supplementation, including improved oxidative stress markers, glucose regulation, lipid profiles, and in both healthy and clinical populations.

• High-intensity interval training (HIIT), particularly the Tabata protocol, is an time-effective and efficient method to enhance aerobic and anaerobic performance, especially in tactical and military populations.

• Military cadets, often face high physical and psychological demands that can lead to inflammation, oxidative stress, and impaired recovery.

• Despite the individual benefits of cinnamon and HIIT, their combined effects on combat readiness, physical performance, and metabolic health have not been thoroughly investigated in military settings.

 

What this study adds?

• This is the first randomized controlled trial to investigate the combined effects of cinnamon supplementation and Tabata-style high-intensity interval training on performance and metabolic outcomes in tactical cadets.  

• The study demonstrates that cinnamon supplementation significantly boosts the physiological benefits of HIIT, including greater improvements in reduced post-exercise blood lactate levels, VO₂max, and superior gains in combat readiness scores.  

• Findings support the integration of traditional herbal medicine with modern exercise protocols as a safe, feasible, and culturally appropriate strategy to optimize recovery and physical performance in military populations.  

• The results provide translational evidence for cinnamon as a functional ergogenic aid that may improve lactate clearance, resilience, and energy metabolism, under high-intensity physical stress.  

• This study introduces a scalable intervention, novel, and low-cost with potential applications in military training, sports performance, and occupational health settings.

 

Keywords

Subjects


Acknowledgements

The authors would like to thank all the participant for their time and effort during the tests.

Funding

This work is based upon research funded by Iran National Science Foundation (INSF) under project No.4027513.

Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Compliance with ethical standards

Conflict of interest The authors declare that there is no conflict of interest in the present research.

Ethical approval This study was approved by the Research Ethics Committee of Islamic Azad University, Ardabil Branch, on 3 March 2025 (Approval Code: IR.IAU.ARDABIL.REC.1403.229). All procedures involving human participants were conducted in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments.

Informed consent All participants were fully informed about the study objectives, procedures, potential risks, and benefits. Written informed consent was obtained from each participant prior to enrollment, and participants were informed that they could withdraw at any stage without penalty. The authors affirm that participants gave informed consent for the publication of anonymized data derived from this study. No personally identifiable information is included in this manuscript. 

Author contributions 

Conceptualization: R.S.R., M.S.K., Methodology: R.S.R., M.S.K., Software: R.S.R., M.S.K., Validation: R.S.R., M.S.K.,; Formal analysis: R.S.R., M.S.K.,; Investigation: R.S.R., M.S.K.,; Resources: R.S.R., M.S.K.,; Data curation: R.S.R., M.S.K.,; Writing - original draft: R.S.R., M.S.K.,; Writing–review & editing R.S.R., M.S.K.,; Visualization: R.S.R., M.S.K.,; Supervision: R.S.R.; Project administration: M.S.K.,.; Funding acquisition: R.S.R.    

Guo, J., Jiang, X., Tian, Y., Yan, S., Liu, J., Xie, J., Zhang, F., Yao, C., & Hao, E. (2024). Therapeutic potential of cinnamon oil: Chemical composition, pharmacological actions, and applications. Pharmaceuticals, 17(12), 1700. https://doi.org/10.3390/ph17121700  
Pagliari, S., Forcella, M., Lonati, E., Sacco, G., Romaniello, F., Rovellini, P., Fusi, P., Palestini, P., Campone, L., Labra, M., Bulbarelli, A., & Bruni, I. (2023). Antioxidant and anti-inflammatory effect of cinnamon (Cinnamomum verum J. Presl) bark extract after in vitro digestion simulation. Foods, 12(3), 452. https://doi.org/10.3390/foods12030452  
Khedkar, S., & Khan, M. A. (2023). Aqueous extract of cinnamon (Cinnamomum spp.): Role in cancer and inflammation. Evidence-Based Complementary and Alternative Medicine, Article ID 5467342. https://doi.org/10.1155/2023/5467342 
Hussain, Z., Khan, J. A., & Rashid, H. (2019). Cinnamomum zeylanicum (Darchini): A boon to medical science and a possible therapy for stress-induced ailments. Critical Reviews in Eukaryotic Gene Expression, 29(3), 263-276. https://doi.org/10.1615/CritRevEukaryotGeneExpr.2019028867 
Sabzevari Rad, R., Omidi, H., & Alipour, M. (2025). The combined effects of Tabata training and cinnamon supplementation on metabolic changes and body composition in soldiers with overweight or obesity. Journal of the International Society of Sports Nutrition, 22(1), Article 2564237. https://doi.org/10.1080/15502783.2025.2564237  
Sabzevari Rad, R., Omidi, H., & Alipour, M. (2024). The effect of Tabata training and cinnamon supplementation on lipid profiles, body composition, aerobic and anaerobic performance in obese and overweight Nezaja soldiers. Journal of Neyshabur University of Medical Sciences, 12(1), 78-94. 
Shang, C., Lin, H., Fang, X., Wang, Y., Jiang, Z., Qu, Y., Xiang, M., Shen, Z., Xin, L., Lu, Y., Gao, J., & Cui, X. (2021). Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes. Food & Function, 12, 12194-12220. https://doi.org/10.1039/D1FO01935J  
Tuzcu, Z., Orhan, C., Sahin, N., Juturu, V., & Sahin, K. (2017). Cinnamon polyphenol extract inhibits hyperlipidemia and inflammation by modulation of transcription factors in high-fat diet-fed rats. Oxidative Medicine and Cellular Longevity, 2017, Article 1583098. https://doi.org/10.1155/2017/1583098   
Sabzevari Rad R. Nutritional and dietary assessment of cadets menus at the Iran Army Military Academy. Discover Food. 2025 Jul 2;5(1):213. 
Tabata, I. (2019). Tabata training: One of the most energetically effective high-intensity intermittent training methods. The Journal of Physiological Sciences, 69(5), 559–572. https://doi.org/10.1007/s12576-019-00676-7  
Gibala, M. J., Gillen, J. B., & Percival, M. E. (2014). Physiological and health-related adaptations to low-volume interval training: Influences of nutrition and sex. Sports Medicine, 44(Suppl 2), 127–137. https://doi.org/10.1007/s40279-014-0259-6  
Viana, R. B., de Lira, C. A. B., Naves, J. P. A., et al. (2019). Tabata protocol: A review of its application, variations and outcomes. Clinical Physiology and Functional Imaging, 39(1), 1–8. https://doi.org/10.1111/cpf.12505  
Domaradzki, J., Cichy, I., Rokita, A., & Popowczak, M. (2020). Effects of Tabata training during physical education classes on body composition, aerobic capacity, and anaerobic performance. International Journal of Environmental Research and Public Health, 17(3), 876. https://doi.org/10.3390/ijerph17030876  
Murawska-Ciałowicz, E., Wolański, P., Zuwala-Jagiełło, J., et al. (2019). Effect of HIIT with Tabata protocol on serum irisin, physical performance, and body composition in men. International Journal of Environmental Research and Public Health, 16(22), 4497. https://doi.org/10.3390/ijerph16224497  
Dorri, M., Hashemitabar, S., & Hosseinzadeh, H. (2018). Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug and chemical toxicology, 41(3), 338-351.
Withrow, K. L., Rubin, D. A., Dawes, J. J., Orr, R. M., Lynn, S. K., & Lockie, R. G. (2023). Army combat fitness test relationships to tactical foot march performance in reserve officers’ training corps cadets. Biology, 12(3), 477.
Knapik, J. J., Sharp, M. A., & Steelman, R. A. (2022). Validity of field-expedient aerobic fitness tests in military populations: A systematic review. Military Medicine, 187(1–2), 123–132. https://doi.org/10.1093/milmed/usab355  
Feito, Y., Brown, C., & Olmos, A. (2019). A content analysis of the high-intensity functional training literature: A look at the past and directions for the future. Human Movement, 20(2), 1-15. https://doi.org/10.5114/hm.2019.81020   
Maierean, S. M., Serban, M.-C., Sahebkar, A., Ursoniu, S., Serban, A., Penson, P., & Banach, M. (2017). The effects of cinnamon supplementation on blood lipid concentrations: A systematic review and meta-analysis. Journal  of Clinical Lipidology, 11(6), 1393-1406.   https://doi.org/10.1016/j.jacl.2017.08.004  
Anderson, R. A. (2008). Chromium and polyphenols from cinnamon improve insulin sensitivity. Nutrition Reviews, 66(10), 578–580.  https://doi.org/10.1111/j.1753-4887.2008.00081.x   
Qin, P., Wang, J., Luo, S., Chen, K., & Zhang, Y. (2003). Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats. Life Sciences, 73(24), 3075–3084. https://doi.org/10.1016/j.lfs.2003.05.006  
Yanaga, Y., Kubota, Y., & Matsumoto, T. (2006). Cinnamaldehyde induces endothelium-dependent and -independent vasorelaxant action on isolated rat aorta. Biological and Pharmaceutical Bulletin, 29(10), 2055–2058. https://doi.org/10.1248/bpb.29.2055  
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008). From inflammation to sickness and depression: When the immune system subjugates the brain. Nature Reviews Neuroscience, 9(1), 46–56. https://doi.org/10.1038/nrn2297  
Angelopoulou, E., Paudel, Y. N., Piperi, C., & Mishra, A. (2021). Neuroprotective potential of cinnamon and its metabolites in Parkinson's disease: Mechanistic insights, limitations, and novel therapeutic opportunities. Journal of Biochemical and Molecular Toxicology, 35(4), e22720. https://doi.org/10.1002/jbt.22720  
Sohrabi, R., Pazgoohan, N., Seresht, H. R., & Amin, B. (2017). Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice. Iranian Journal of Basic Medical Sciences, 20(6), 708–715. https://doi.org/10.22038/IJBMS.2017.8890  
Gu, Y., Lin, S., Li, Y., Wang, Y., & Zhang, H. (2022). Safety of Cinnamon: An Umbrella Review of Meta-Analyses and Systematic Reviews of Randomized Clinical Trials. Nutrients, 14(1), 195. https://doi.org/10.3390/nu14010195  
Brooks, G. A. (2020). Lactate as a fulcrum of metabolism. Redox Biology, 35, 101454. https://doi.org/10.1016/j.redox.2020.101454  
Hashimoto, T., & Brooks, G. A. (2008). Mitochondrial lactate oxidation complex and an adaptive role for lactate production. Medicine & Science in Sports & Exercise, 40(3), 486-494.
Shen, Y., Honma, N., Kobayashi, K., Jia, L. N., Hosono, T., Shindo, K., ... & Seki, T. (2014). Cinnamon extract enhances glucose uptake in 3T3-L1 adipocytes and C2C12 myocytes by inducing LKB1-AMP-activated protein kinase signaling. PLoS One, 9(2), e87894. 
Ziegenfuss, T. N., Hofheins, J. E., Mendel, R. W., Landis, J., & Anderson, R. A. (2006). Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. Journal of the International Society of Sports Nutrition, 3(2), 45.
Mang, B., Wolters, M., Schmitt, B., Kelb, K., Lichtinghagen, R., Stichtenoth, D. O., & Hahn, A. (2006). Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2. European journal of clinical investigation, 36(5), 340-344. 
Schink, A., Naumoska, K., Kitanovski, Z., Kampf, C. J., Fröhlich-Nowoisky, J., Thines, E., & Lucas, K. (2018). Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways. Food & function, 9(11), 5950-5964. https://doi.org/10.1039/c8fo01286e  
Bahri, S., Adnyana, I. K., Hasan, M. F., Apriantono, T., & Juniarsyah, A. D. (2022). The Effect of Cinnamon Extract on Recovery and Performance of Weightlifting Athletes. Sport Mont, 20(2), 57-61. https://doi.org/10.26773/smj.220609 
Wood dos Santos, T., Hernandes, N. A., Simionato, G., Marostegan, G., Roschel, H., Gualano, B., … Lugaresi, R. (2018). Effects of polyphenols on thermogenesis and mitochondrial biogenesis: Implications for obesity and metabolic health. International Journal of Molecular Sciences, 19(9), 2757. https://doi.org/10.3390/ijms19092757  
Dehghan, G., Shaghaghi, M., Jafari, A., Mohammadi, M., & Badalzadeh, R. (2025). Effect of endurance training and cinnamon supplementation on post-exercise oxidative responses in rats. Molecular Biology Research Communications. Retrieved from https://mbrc.shirazu.ac.ir/article2723.html  
Moradi Talgerd, H., Koushkie Jahromi, M., & Salesi, M. (2023). Effect of cinnamon on immune responses to an exhaustive exercise session in active boys. Journal of Sports Biology. Retrieved from https://jsb.ut.ac.ir/article92498.html  
Pedersen, B. K., & Febbraio, M. A. (2012). Muscles, exercise and obesity: Skeletal muscle as a secretory organ. Nature Reviews Endocrinology, 8(8), 457–465. https://doi.org/10.1038/nrendo.2012.49  
 
 
Volume 5, Issue 4
Autumn 2025
Pages 168-179

  • Receive Date 31 October 2025
  • Revise Date 15 November 2025
  • Accept Date 20 November 2025