Journal of Exercise & Organ Cross Talk
Journal of Eexercise & Organ Cross Talk

Training-specific effects on metabolic-inflammatory mediators: GLP-1 and Dectin-1 changes following resistance, continuous, or interval exercise in overweight women

Document Type : Original Article

Authors

Leila Nouri Ain 1
Valiollah Shahedi 2
Yaser Kazemzadeh 3
Sanaz Mirzaian Shanjani 3
Sajad Arshadi 4

1 PhD student in exercise physiology, Department of Exercise Physiology, I.C., Islamic Azad University, Tehran, Iran.

2 Assistant Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, P.C., Islamic Azad University, Tehran, Iran.

3 Assistant Professor of Exercise Physiology, Department of Exercise Physiology, I.C., Islamic Azad University, Tehran, Iran.

4 Associate Professor, Department of Exercise Physiology, Faculty of Sport Sciences, ST.C., Islamic Azad University, Tehran, Iran.

https://doi.org/10.22122/jeoct.2025.527837.1157
Abstract
The purpose of this study was to examine the effects of eight weeks of resistance, continuous endurance, and interval endurance training on Dectin-1 and Glucagon-Like Peptide-1 levels in overweight women. A total of 40 women, aged between 25 and 35 years with a body mass index (BMI) ranging from 25 to 30 kg/m², voluntarily participated in the study. Participants were randomly assigned to one of four groups: resistance training (n = 10), continuous endurance training (n = 10), interval endurance training (n = 10), and a non-training control group (n = 10). The intervention consisted of three exercise sessions per week over an eight-week period, following structured and group-specific training protocols. Results indicated that all three exercise modalities—resistance, continuous endurance, and interval training— significantly altered Dectin-1 and GLP-1 levels compared to the control group (p < 0.05). Among the training groups, continuous endurance training elicited the greatest reduction in Dectin-1 levels, followed by interval training and then resistance training. However, post hoc analysis revealed no significant difference between resistance and interval training groups for either biomarker. Similarly, GLP-1 levels increased most prominently in the continuous endurance group, followed by the interval and resistance training groups, again with no significant difference between the latter two. In summary, the findings suggest that all three forms of exercise contributed to favorable changes in Dectin-1 and GLP-1 among overweight women. Nonetheless, the magnitude of these changes appears to be influenced by the type and possibly the intensity of the training stimulus, with continuous endurance training demonstrating the most pronounced effects.

What is already known on this subject?

Obesity and overweight due to increased fat mass are usually associated with increased plasma glucose levels and increased insulin resistance.

 

What this study adds?

The present study showed that different training methods have significant effects on each of the GLP-1 and dectin-1 indices in overweight women. Tukey's post hoc test showed that continuous aerobic training had the greatest increasing effect on GLP-1 compared to other groups, followed by interval training and finally resistance training, which had greater increasing effects, but this effect was not significant between resistance and interval training. Also, continuous aerobic training had the greatest decreasing effect on dectin-1 compared to other groups, followed by interval training and finally resistance training, which had decreasing effects, but this effect was not significant between resistance and interval training. In general, it can be concluded that the type of training can have different and significant effects on each of the inflammatory-metabolic indices.

Keywords

Interval endurance training
Continuous endurance training
Resistance training
GLP-1
Dectin-1

Subjects

Acknowledgements

The present study is the result of the findings of a doctoral thesis approved by Islamic Azad University, Islamshahr Branch. The researchers also express their gratitude and appreciation to the respected laboratory officials who helped us in this project.

Funding

No sources of funding were sought or awarded for this study.

Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Compliance with ethical standards

Conflict of interest The authors declare that they have no conflict of interest.

Ethical approval the study protocol conformed to the Declaration of Helsinki and was approved by the animal care and use committee of Islamic Azad University parand Tehran branch (Ethical code IR.IAU.PIAU.REC.1403.032).

Informed consent Participants signed an informed consent form prior to participation in the study.

Author contributions

Conceptualization: L.N.A, V.SH,; Methodology: L.N.A, V.SH, Y.K, S.M.S, S.A,; Software: L.N.A, V.SH, Y.K, S.M.S, S.A,;   Validation: L.N.A, V.SH, Y.K, S.M.S, S.A,;  Formal analysis: L.N.A, V.SH, Y.K, S.M.S, S.A,;  Investigation: L.N.A, V.SH, Y.K, S.M.S, S.A,;  Resources: L.N.A, V.SH, Y.K, S.M.S, S.A,;  Data curation: L.N.A, V.SH, Y.K, S.M.S, S.A,; Writing - original draft: L.N.A, V.SH, Y.K, S.M.S, S.A,;  Writing - review & editing L.N.A, V.SH, Y.K, S.M.S, S.A,; Visualization: L.N.A, V.SH, Y.K, S.M.S, S.A,; Supervision: L.N.A, V.SH, Y.K, S.M.S, S.A,; Project administration: L.N.A, V.SH, Y.K, S.M.S, S.A,; Funding acquisition: L.N.A, V.SH, Y.K, S.M.S, S.A.

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Journal of Exercise & Organ Cross Talk
Volume 5, Issue 1
Winter 2025
Pages 33-39

  • Receive Date 02 January 2025
  • Revise Date 17 March 2025
  • Accept Date 28 March 2025

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