Journal of Eexercise & Organ Cross Talk

Promoting brain health in older adults through exercise: A narrative review of the role of muscle-brain crosstalk

Document Type : Review Articles

Authors

Department of Exercise Physiology, Faculty of Sport Sciences, University of Isfahan, Isfahan, Iran.

Abstract
This article explores the impact of exercise training on brain health in older adults, focusing on the concept of muscle-brain crosstalk. As the global population ages, understanding how lifestyle interventions like exercise can support cognitive function is increasingly important. The article reviews evidence suggesting that physical activity, particularly aerobic and resistance training, plays a crucial role in maintaining and enhancing brain health. It discusses the mechanisms underlying the beneficial effects of exercise, including improved blood flow, neurogenesis, and the release of myokines proteins produced by muscle contractions that influence brain function. Additionally, the article highlights how these myokines facilitate communication between muscles and the brain, contributing to neuroplasticity, reduced inflammation, and enhanced cognitive abilities. The concept of muscle-brain crosstalk is emphasized as a key factor in understanding how exercise promotes brain health, with potential implications for designing targeted interventions to preserve cognitive function in older adults. The article concludes by suggesting that regular exercise should be a cornerstone of public health strategies aimed at improving the quality of life and cognitive health in aging populations. Further research is encouraged to deepen our understanding of the molecular pathways involved and to develop personalized exercise programs that maximize brain health benefits for older adults.

What is already known on this subject?

Engaging in physical activity, particularly aerobic exercise, is essential for preserving the structural integrity of neurons and maintaining overall brain volume.

 

What this study adds?

We consider how exercise can promote brain health in aging populations through new mechanisms such as muscle-brain crosstalk.

Keywords

Subjects


Acknowledgements

None.

Funding

No funding.

Compliance with ethical standards

Conflict of interest The authors declare that they have no conflict of interest.

Ethical approval Not applicable.

Informed consent Not applicable

Author contributions

Conceptualization: S.A, M.F.; Methodology: S.A, M.F.; Software: None.; Validation: S.A, M.F., Formal analysis: none.; Investigation: S.A, M.F.; Resources: S.A, M.F.; Data curation: None.; Writing - original draft: S.A, M.F.; Writing – review & editing: S.A, M.F.; Visualization: S.A, M.F.; Supervision: M.F. Project administration: S.A, M.F.; Funding acquisition: M.F.

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Volume 4, Issue 2
Spring 2024
Pages 145-156

  • Receive Date 15 March 2024
  • Revise Date 12 June 2024
  • Accept Date 19 June 2024