Journal of Eexercise & Organ Cross Talk

The effect of exercise on autophagy receptors and ubiquitin-dependent mitophagy pathway: Narrative review

Document Type : Review Articles

Authors

1 Department of Exercise Physiology, Karaj Branch, Islamic Azad University, Karaj, Iran.

2 Teacher of Sama Elementary School, Education Office, Quchan, Iran.

3 AJA Exercise Physiology Committee, Tehran, Iran.

4 Department of Biology, Yadegar-e-Imam Khomeini (RAH) Shahre Rey Branch, Islamic Azad University, Tehran, Iran

Abstract
Most of the intracellular and extracellular factors that play a vital role in regulating energy metabolism and determining cell fate converge in the mitochondria. To promote or hinder cell survival through regulating the function and maintaining the mitochondrial structure. The decline of mitochondrial function and homeostasis with aging is the basis of the pathogenesis of aging-related diseases, especially in skeletal muscles. One of the important components of mitochondrial quality control that helps maintain the homeostasis of myocytes is autophagy, which is an important biological and evolutionary process, and its vital function is the removal of defective organelles. Although it has been proven that regular sports activities act as autophagy stimulators and play a role in maintaining the cellular homeostasis of skeletal muscle fibers and regulating intracellular metabolism. However, cellular autophagic responses to exercise in skeletal muscle appear to be different in different exercise protocols and disease models. How exercise activity modulates autophagy in skeletal muscle and how the effect of exercise is regulated by the autophagy signaling pathway are still poorly understood. The importance of understanding the obscure angles of this process can be an important goal in preventing the pathology of age-related diseases in skeletal muscle.

What is already known on this subject?

Autophagy is a cellular recycling process that breaks down and reuses damaged or unnecessary components. Theses procese can activate with different exercise training.

 

What this study adds?

Because doing regular physical activities as a stimulus for the autophagy mechanism in skeletal muscles can help to regulate the metabolism of myocytes in addition to modulating this mechanism.

Keywords

Subjects


Acknowledgements

None.

Funding

None of the researchers received financial support.

Compliance with ethical standards

Conflict of interest The authors declare that they have no conflict of interest.

Ethical approval Not applicable

Informed consent Not applicable.

Author contributions

Conceptualization: S.E, M.M, A.F,F.R.; Methodology: S.E, M.M, A.F,F.R, Software: -.; Validation: S.E, M.M, A.F,F.R.; Formal analysis: -.; Investigation: S.E, M.M, A.F,F.R.; Resources: S.E, M.M, A.F,F.R.; Data curation: -.; Writing - original draft: S.E, M.M, A.F,F.R.; Writing - review & editing: S.E, M.M, A.F,F.R.; Visualization: S.E, M.M, A.F,F.R.; Supervision: F.R.; Project administration: S.E.; Funding acquisition: F.R.

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Volume 4, Issue 2
Spring 2024
Pages 133-144

  • Receive Date 07 April 2024
  • Revise Date 14 June 2024
  • Accept Date 18 June 2024