Exercise training increases the chance of the body's immune system to fight against the disease of Covid-19: A mini review of exercise, immune system and myokines

Document Type : Review Articles


1 PhD Student of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

2 PhD, Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.


The covid-19 disease has spread all over the world since 2019 and many people have been affected by this disease. One of the main characteristics of this disease was lung tissue damage, which subsequently affected the immune system as well. In other words, since there are no registered drugs or vaccines against COVID-19, the immune system is the best defense because it supports the body's natural ability to defend against pathogens and resist infections. As long as the immune system is working normally, infections like COVID-19 cannot cause serious damage to the body. The three types of immunity are: innate immunity (fast response), adaptive immunity (slow response), and passive immunity. Strengthening the immune system can guarantee a better fight against pathogens. Exercising can help strengthen the immune system. In other words, exercise is one of the non-pharmacological factors for controlling diseases related to the immune system. Recently, it has been identified that exercise training with muscle contraction, the secretion of myokines in an endocrine form can affect all body tissues. One of the target tissues of myokines is the immune system. Therefore, this study deals with the strengthening role of the immune system due to exercise and muscle contraction in the conditions of the Covid-19 epidemic.

What is already known on this subject?

Many studies have been conducted on the role of physical stress as a factor stimulating the immune system.


What this study adds?

Regular exercise with low to moderate intensity can be recommended for healthy people in order to benefit from other best effects of exercise training especially with myokine secretion.


Main Subjects





Compliance with ethical standards

Conflict of interest No conflict of interest.

Ethical approval Not applicable.

Informed consent Not applicable.

Author contributions

Conceptualization: R.Sh.; Methodology: AH.H.; Software: None; Validation: R.Sh, AH.H.; Formal analysis: None; Investigation: R.Sh, AH.H.; Resources: R.Sh, AH.H.; Data curation: R.Sh, AH.H.; Writing - original draft: R.Sh, AH.H.; Writing - review & editing: R.Sh, AH.H.; Visualization: R.Sh, AH.H.; Supervision: R.Sh.; Project administration: R.Sh.; Funding acquisition: None.

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