A survey of two submaximal exercise training on a C-reactive protein in the elderly man

Document Type : Original Article

Authors

1 PhD Student of Exercise Physiology, Faculty of Sport Sciences, Esfahan Islamic Azad University (Khorasgan).

2 Master student of Department of Wellness, Sport and Health, University of Bologna, Rimini, Italy.

3 Department of Health and Sport Medicine, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.

Abstract

The purpose of this research is to survey the effect of eight weeks of sub-maximal training on the C-Reactive Protein (CRP) in elderly males. The subjects of the research consisted of 21 elderly males between 50-80 years old, divided into two groups (one experimental group and one control group), with VO2Peak values of 51.14±2.7, 51.92±3.17, and 43.61±1.85 (based on the 1-mile (1609 meters) Track Jog test). The experimental group carried out Balke-Ware sub-maximal aerobic exercise 5 sessions a week for 8 weeks, while the control group did not participate in the training program. The results of the research showed that the average CRP levels decreased in the experimental group, while they increased in the control group. However, these differences were not statistically significant according to the paired sample T-Test results. On the other hand, a significant difference in Vo2 Peak was observed between the two groups (p<0.039 and p<0.001), with the experimental group showing higher values compared to the control group. Additionally, there was no statistically significant difference in HS-CRP levels between the subjects (experimental group 1, experimental group 2, and control group) before and after the training period. In general, it seems that a longer duration is required to observe better markers of inflammatory and cardiovascular effects of these variables. The pre-study hypothesis of cardiorespiratory fitness on CRP response confirms that assessing control and inflammatory markers of cardiorespiratory fitness in the elderly requires more time.

What is already known on this subject?

The elderly are a natural phenomenon, in which the physical, mental, and psychological activities of the person have decreased, and these physiological changes are the same in different people, but the speed of doing it can be different.

 

What this study adds?

A longer duration is required to observe better markers of inflammatory and cardiovascular effects of these variables.

Keywords

Main Subjects


Acknowledgements

None.

Funding

None.

Compliance with ethical standards

Conflict of interest The authors declare that they have no conflict of interest.

Ethical approval Animals had free access to standard food and water. All stages of keeping and slaughtering rats were carried out according to the rules of the Animal Ethics Committee of Islamic Azad University, Rasht Branch (ethical code: IR.IAU.RASHT.REC.1399.024).

Informed consent It was perform at first of study.

Author contributions

Conceptualization: S.A., M.F.S.; Methodology: M.R.; Software: S.A.; Validation: M.F.S.; Formal analysis: M.R.; Investigation: M.R.; Resources: M.F.S.; Data curation: S.A., M.R.; Writing - original draft: M.F.S.; Writing – review & editing: M.R.; Visualization: S.A., M.R.; Supervision: S.A.; Project administration: S.A., M.F.S.; Funding acquisition: S.A.

Akbari, Hamza. Segoryan, Bakhtiar. Amirsasan, Ramin; 2018. The effect of L-carnitine supplementation on 6-IL and CRP during a course of swimming training in male swimmers, Olympics, 17th year, number 4, 94.
Albert, Christine M, Ma, Jing, Rifai, Nader, Stampfer, Meir J, & Ridker, Paul M. (2002). Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation, 105(22), 2595-2599. doi: https://doi.org/10.1161/01.CIR.0000017493.03108.1C
Bermudez, Edmund A, Rifai, Nader, Buring, Julie, Manson, JoAnn E, & Ridker, Paul M. (2002). Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women. Arteriosclerosis, thrombosis, and vascular biology, 22(10), 1668-1673. doi: https://doi.org/10.1161/01.ATV.0000029781.31325.66
Cavalié, H, Horcajada-Molteni, MN, Lebecque, P, Davicco, MJ, Coxam, V, Lac, G, & Barlet, JP. (2003). Progressive isometric force training and bone mass in rats. Journal of Musculoskeletal and Neuronal Interactions, 3(1), 47-52.
Christos, K, & Paul, DT. (2005). The effects of physical activity on serum C-reactive protein and inflammatory markers. J Am Coll Cardiol, 45(10), 1563-1569. URL: https://www.jacc.org/doi/abs/10.1016/j.jacc.2004.12
Dadkhah, Asghar, 2016, the system of special services for the elderly in America and Japan and providing indicators for developing a strategic plan for the elderly in Iran, Ageing, second year, (3): 167.
Debidi Roshan, Wali Allah. Mahmoudi, Seyyed Ali Akbar. Jolazadeh, Tala; 2018. Comparison of the effect of 3 and 5 cycles of aerobic interval training on HS-CRP of female Wistar rats, Olympic, 17th year, number 1, 116_112.
Duey, WJ, O'Brien, WL, Crutchfield, AB, Brown, LA, Williford, HN, & Sharff-Olson, M. (1998). Effects of exercise training on aerobic fitness in African-American females. Ethnicity & disease, 8(3), 306. URL: https://www.jstor.org/stable/45410234
Ernst, Edzard, & Resch, Karl Ludwig. (1993). Fibrinogen as a cardiovascular risk factora meta analysis and review of the literature. Annals of Internal Medicine, 118(12), 956-963. doi: https://doi.org/10.7326/0003-4819-118-12-199306150-00008
Gaini, Abbas Ali. Rajabi, Hamid; 2012. Physical fitness. First edition, Tehran, Semat Publications.
Gielen, Stephan, Adams, Volker, Möbius-Winkler, Sven, Linke, Axel, Erbs, Sandra, Yu, Jiangtao, Hambrecht, Rainer. (2003). Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. Journal of the American College of Cardiology, 42(5), 861-868. URL: https://www.jacc.org/doi/abs/10.1016/S0735-1097(03)00848-9
Hu, Frank B, Meigs, James B, Li, Tricia Y, Rifai, Nader, & Manson, JoAnn E. (2004). Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes, 53(3), 693-700. doi: https://doi.org/10.2337/diabetes.53.3.693
Khalili, Majid. Mohajal Sheja, Muhammad Ali. Ismaili Prapari, Shiva. Batani, Gholamreza;    2018. The role of exercise in old age from the point of view of Razi, Hakim Misri, Ibne Sina and Jarjani, Medical History Quarterly, 3rd year, 7th issue, 60-68.
Marcell, Taylor J, McAuley, Kirsten A, Traustadóttir, Tinna, & Reaven, Peter D. (2005). Exercise training is not associated with improved levels of C-reactive protein or adiponectin. Metabolism, 54(4), 533-541. doi: https://doi.org/10.1016/j.metabol.2004.11.008
 Meng, H, & Pierce, GN. (1990). Metabolic and physiological response of the rabbit to continuous and intermittent treadmill exercise. Canadian journal of physiology and pharmacology, 68(7), 856-862. doi: https://doi.org/10.1139/y90-130
Ockene, IS, Chiriboga, DE, & Stanek, EJ. (2004). Seasonal variation in serum cholesterol levels. ACC Current Journal Review, 13(6), 23-24. doi: https://doi.org/10.1001/archinte.164.8.863
O'Donovan, Gary, Owen, Andrew, Bird, Steve R, Kearney, Edward M, Nevill, Alan M, Jones, David W, & Woolf-May, Kate. (2005). Changes in cardiorespiratory fitness and coronary heart disease risk factors following 24 wk of moderate-or high-intensity exercise of equal energy cost. Journal of Applied Physiology, 98(5), 1619-1625.  doi: https://doi.org/10.1152/japplphysiol.01310.2004
Phillips, TRACEY, Childs, APRIL C, Dreon, DARLENE M, Phinney, STEPHEN, & Leeuwenburgh, CHRISTIAAN. (2003). A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. Medicine and science in sports and exercise, 35(12), 2032-2037. doi: https://doi.org/10.1249/01.mss.0000099112.32342.10
Plaisance, Eric P, & Grandjean, Peter W. (2006). Physical activity and high-sensitivity C-reactive protein. Sports Medicine, 36(5), 443-458. doi: https://doi.org/10.2165/00007256-200636050-00006
Powers, Scott K, Ji, LL, & Leeuwenburgh, CHRISTIAAN. (1999). Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Medicine and science in sports and exercise, 31(7), 987-997. doi: https://doi.org/10.1097/00005768-199907000-00011
Ridker, Paul M, Glynn, Robert J, & Hennekens, Charles H. (1998). C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation, 97(20), 2007-2011. doi: https://doi.org/10.1161/01.CIR.97.20.2007
 Rodnick, KJ, Reaven, GM, Haskell, WL, Sims, CR, & Mondon, CE. (1989). Variations in running activity and enzymatic adaptations in voluntary running rats. Journal of Applied Physiology, 66(3), 1250-1257. doi: https://doi.org/10.1152/jappl.1989.66.3.1250
Schachter, Morey, Raziel, Arieh, Friedler, Shevach, Strassburger, Deborah, Bern, Orna, & Ron‐El, Raphael. (2003). Insulin resistance in patients with polycystic ovary syndrome is associated with elevated plasma homocysteine. Human Reproduction, 18(4), 721-727. doi: https://doi.org/10.1093/humrep/deg190
Sohaili, Shahram. Gayini, Abbas Ali. Suri, Rahman; 2018. The effect of resistance training on systemic inflammatory indices in elderly men, Olympic, 17th year, number 4, 52-53.
 Stauffer, Brian L, Hoetzer, Greta L, Smith, Derek T, & DeSouza, Christopher A. (2004). Plasma C-reactive protein is not elevated in physically active postmenopausal women taking hormone replacement therapy. Journal of Applied Physiology, 96(1), 143-148. doi: https://doi.org/10.1152/japplphysiol.00360.2003
 Turk, James R, & Laughlin, M Harold. (2004). Physical activity and atherosclerosis: which animal model? Canadian journal of applied physiology, 29(5), 657-683. doi: https://doi.org/10.1139/h04-042
Van den Burg, PJM, Hospers, JEH, Mosterd, WL, Bouma, BN, & Huisveld, IA. (2000). Aging, physical conditioning and exercise-induced changes in hemostatic factors and reaction products. Journal of Applied Physiology, 88(5), 1558-1564. doi: https://doi.org/10.1152/jappl.2000.88.5.1558
Yarnell, John, McCrum, Evelyn, Rumley, Ann, Patterson, Christopher, Salomaa, Veikko, Lowe, Gordon, & Evans, Alun. (2005). Association of European population levels of thrombotic and inflammatory factors with risk of coronary heart disease: the MONICA Optional Haemostasis Study†. European heart journal, 26(4), 332-342. doi: https://doi.org/10.1093/eurheartj/ehi052