A survey of two submaximal exercise training on a C-reactive protein in the elderly man

Document Type : Original Article


1 PhD Student of Exercise Physiology, Faculty of Sport Sciences, Esfahan Islamic Azad University (Khorasgan).

2 Master student of Department of Wellness, Sport and Health, University of Bologna, Rimini, Italy.

3 Department of Health and Sport Medicine, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran.


The purpose of this research is to survey the effect of eight weeks of sub-maximal training on the C-Reactive Protein (CRP) in elderly males. The subjects of the research consisted of 21 elderly males between 50-80 years old, divided into two groups (one experimental group and one control group), with VO2Peak values of 51.14±2.7, 51.92±3.17, and 43.61±1.85 (based on the 1-mile (1609 meters) Track Jog test). The experimental group carried out Balke-Ware sub-maximal aerobic exercise 5 sessions a week for 8 weeks, while the control group did not participate in the training program. The results of the research showed that the average CRP levels decreased in the experimental group, while they increased in the control group. However, these differences were not statistically significant according to the paired sample T-Test results. On the other hand, a significant difference in Vo2 Peak was observed between the two groups (p<0.039 and p<0.001), with the experimental group showing higher values compared to the control group. Additionally, there was no statistically significant difference in HS-CRP levels between the subjects (experimental group 1, experimental group 2, and control group) before and after the training period. In general, it seems that a longer duration is required to observe better markers of inflammatory and cardiovascular effects of these variables. The pre-study hypothesis of cardiorespiratory fitness on CRP response confirms that assessing control and inflammatory markers of cardiorespiratory fitness in the elderly requires more time.

What is already known on this subject?

The elderly are a natural phenomenon, in which the physical, mental, and psychological activities of the person have decreased, and these physiological changes are the same in different people, but the speed of doing it can be different.


What this study adds?

A longer duration is required to observe better markers of inflammatory and cardiovascular effects of these variables.


Main Subjects





Compliance with ethical standards

Conflict of interest The authors declare that they have no conflict of interest.

Ethical approval Animals had free access to standard food and water. All stages of keeping and slaughtering rats were carried out according to the rules of the Animal Ethics Committee of Islamic Azad University, Rasht Branch (ethical code: IR.IAU.RASHT.REC.1399.024).

Informed consent It was perform at first of study.

Author contributions

Conceptualization: S.A., M.F.S.; Methodology: M.R.; Software: S.A.; Validation: M.F.S.; Formal analysis: M.R.; Investigation: M.R.; Resources: M.F.S.; Data curation: S.A., M.R.; Writing - original draft: M.F.S.; Writing – review & editing: M.R.; Visualization: S.A., M.R.; Supervision: S.A.; Project administration: S.A., M.F.S.; Funding acquisition: S.A.

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