Effect of six weeks of interval training and curcumin consumption on apolipoprotein A and B in diabetic male rats

Document Type : Original Article


1 Master's Degree in Sports Physiology, Sports Nutrition, Faculty of Physical Education, Islamic Azad University, Ahvaz Branch, Iran.

2 Ph.D. in Biochemistry and Sports Metabolism, Department of Physical Education, Faculty of Humanities, Islamic Azad University, Ahvaz Branch, Iran.

3 PhD student in sports physiology, Faculty of Sports Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.


The present study was conducted to investigate the effect of six weeks of intermittent exercise and curcumin consumption on plasma Apo A and Apo B concentrations in male Wistar rats. 30 male Wistar rats were randomly divided into six groups (5 rats in each group): control, diabetic, healthy intermittent exercise, intermittent exercise diabetes, curcumin diabetes and curcumin exercise diabetes. Diabetes was induced by intraperitoneal injection of streptozotocin poison (50 mg/kg). Intermittent training consisted of 5-12 bouts of intense work (75 to 100% of maximum speed) of 60 seconds with active rest intervals of 75 seconds, six days a week for six weeks. Curcumin was fed to animals by gavage at a dose of 50 mg per kilogram of body weight. The results demonstrated that diabetes induction significantly decreased plasma Apo A concentration (p≤0.01) and increased plasma Apo B concentration (p≤0.01). Intermittent training caused a significant increase in Apo A and a significant decrease in Apo B plasma in diabetic rats. Also, it was found that six weeks of curcumin consumption significantly increased the concentration of Apo A in plasma and decreased the concentration of Apo B and the ratio of Apo B to Apo A (p≤0.01). At end, the results of the present study showed that intermittent exercise, curcumin and the combination of two interventions improve the disorders caused by diabetes in apolipoproteins.

What is already known on this subject?

The evidence shows that most of the studies on the effect of curcumin and exercise were done separately on the concentration of Apo A and Apo B and the ratio of Apo B to Apo A in serum and diabetes.


What this study adds?

HIIT, curcumin and the combination of two interventions improve the disorders caused by diabetes at apolipoproteins.


Main Subjects


The following article is taken from the master's thesis of Negar Suleimani, which was carried out at the reproduction and maintenance center of the Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz. We thank and appreciate all the people who helped us in the implementation of this research.



Compliance with ethical standards

Conflict of interest The authors declare that they have no conflict of interest.

Ethical approval Experimental protocols were approved by the Ethics Committee of Islamic Azad University, Ahvaz, Iran (Ethcal code: IR.IAU.AHVAZ.REC.1400.056).

Informed consent Animal study.

Author contributions

Conceptualization: N.S., M.G., R.SH.; Methodology: N.S., M.G., R.SH.; Software: R.SH.; Validation: N.S., M.G.; Formal analysis: N.S., M.G.; Investigation: N.S., M.G.; Resources: N.S., M.G.; Data curation: N.S., M.G., R.SH.; Writing - original draft: N.S., M.G., R.SH.; Writing – review & editing N.S., M.G.; Visualization: N.S., M.G.; Supervision: N.S., M.G.; Project administration: N.S., M.G., R.SH.; Funding acquisition: R.SH.

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