Aging, immune system, and physical activity: A review of recent studies

Document Type : Review Articles


1 Associate Prof, Department of Physical Education, Faculty of Letters and Humanities, Vali-e-Asr University, Rafsanjan, Iran.

2 PhD Student in Exercise Physiology, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.


The immune system is one of the main defenders of human health. The immune system can fight off viruses in the body and kill them. Therefore, keeping the components of the immune system healthy is very important. With age, the immune system ages, and its function decreases. This decline in immune function can easily lead to viral infections in the elderly. Evidence is accumulated that the best solution to maintain and enhance the immune system in the elderly is physical activity. Regular physical activity can lead to healthy aging of the immune system. Therefore, in this review study, we have discussed the changes in the immune system during aging and physical activity suggestions for healthy aging of the immune system. Finally, future research needs are reported.

What is already known on this subject?

With age, the function of the immune system decreases, and this can increase the severity of the disease in the elderly and lead to death in most cases.


What this study adds?

Moderate intensity training (aerobic and resistance training) under the supervision of an expert can lead to the improvement of the body's immune system and reduce the severity of the disease in the elderly.


Main Subjects





Compliance with ethical standards

Conflict of interest The author declare that she has no conflict of interest.

Ethical approval Not applicable.

Informed consent Not applicable.

Author contributions

Conceptualization: A.K.; Methodology: Ah.Ah.; Software: None.; Validation: A.K.; Formal analysis: None.; Investigation: Ah.Ah.; Resources: Ah.Ah.; Data curation: A.K.; Writing - original draft: Ah.Ah.; Writing - review & editing: A.K.; Visualization: Ah.Ah.; Supervision: Ah.Ah.; Project administration: A.K.; Funding acquisition: Ah.Ah.

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