Moderate-intensity continuous training and probiotic consumption on IL-15 gene expression in an animal model of non-alcoholic steatosis

Document Type : Original Article


Department of Physical Education and Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran.


Steatosis is the most important cause for chronic liver disease, from simple steatosis to advanced stages such as liver fibrosis and cirrhosis and liver cancer. In this study, the effect of MICT and probiotic consumption on IL15 gene expression in animal model of non-alcoholic steatosis was examined. This study is an experimental laboratory study. Thirty-two male wistar rats were divided into 4 groups of 8 in the healthy (normal diet), steatosis, steatosis + probiotic, steatosis + probiotic +MICT groups and tested for 8 weeks. The exercise protocol was as follows: in the first week from 10 minutes of running at a speed of 18 meters per minute to the eighth week with 60 minutes of running at a speed of 28 meters per minute. Consumption of probiotics; Relevant groups received 109 CFU / ml of Lactobacillus rhamnosus GG by gavage daily for 5 weeks and 5 days a week. Statistical calculation of this study was performed using SPSS 25 software. Probiotic consumption and moderate-intensity continuous training significantly increased IL-15 (p =0.000) and significantly decreased TG (p =0.000) in the non-alcoholic steatosis animal model. It seems moderate-intensity continuous training with probiotic consumption can improve the liver function of non-alcoholic fatty liver patients.

What is already known on this subject?

Although the number of studies on IL15 measures has increased in the last years, to date, it remains an open question whether the existing effect of exercise and probiotic consumption on immune system measures are appropriate for non-alcoholic fatty liver.


What this study adds?

Moderate-intensity continuous training with probiotic consumption can improve the liver function of non-alcoholic fatty liver patients


Main Subjects

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