The effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer's rats by trimethyltin chloride

Document Type : Original Article


1 Department of Physical Education and Sport Sciences, Yadegar-e-Imam Khomeini (RAH) Shahr-e Ray Branch, Islamic Azad University, Tehran, Iran

2 M.Sc. in Exercise Physiology, Marvdasht branch, Islamic Azad University, Marvdasht, Iran.


There is no treatment for Alzheimer's disease. However, some treatments can have a slowing and controlling effect on the disease process. The aim of this study was to investigate the effect of aerobic training with saffron extract on plasma levels of apo E4 and presenilin gene in Alzheimer's rats by trimethyltin chloride. In this experimental study, 32 male Sprague-Dawley rats with the weight of 180±20 g were selected and after Alzheimer's induction (by intraperitoneal injection of 80 mg/kg trimethyltin chloride) were randomly divided into 4 groups; control, aerobic training, saffron extract, saffron extract- aerobic training. Saffron extract was injected intraperitoneally at the dose of 25 mg/kg daily for eight weeks. The aerobic training program consisted of incremental running on the treadmill at a speed of 15 to 20 m/min and 15 to 30 min per session and 3 sessions per week for 8 weeks. Data were analyzed using two-way ANOVA at the P<0.05. The results showed that aerobic training (P=0.13), saffron extract (P=0.14) and the interaction of aerobic training and saffron extract (P=0.13) had no significant effect on apo E4in rats. Also, aerobic training (P=0.68), saffron consumption (P=0.67) and interaction of aerobic training and saffron extract (P=0.32) had no significant effect on persniline gene in rats. According to the results, it seems that aerobic training and saffron extract do not significantly alter the levels of apo E4 and the presenilin of Alzheimer's rats.

What is already known on this subject?

The interactive effects of exercise training and saffron extract on apo E4 and presenilin genes in Alzheimer's rats have been studied and our information in this field is insufficient.


What this study adds?

It seems that aerobic exercise and saffron extract do not significa ntly alter the levels of apo E4 and the presenilin of Alzheimer's rat.


Main Subjects

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Volume 2, Issue 1
March 2022
Pages 15-21
  • Receive Date: 02 January 2022
  • Revise Date: 07 March 2022
  • Accept Date: 18 March 2022
  • First Publish Date: 18 March 2022