Possible crosstalk between leptin and insulin resistance in sedentary obese boys at different stages of puberty

Document Type : Original Article

Authors

1 Assistant Professor, Department of Physical Education, Faculty of Humanities, Islamic Azad University, Rasht Branch, Rasht, Iran.

2 Faculty of Physical Education and Sport Sciences, Department of Exercise Physiology, University of Guilan, Rasht, Iran

3 Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

Abstract

Puberty with interactive growth in tissues is a sensitive period in life that can be more affected by obesity. Also the increase of leptin and insulin resistant independent of obesity have been seen in puberty. The aim of our study was to investigate the role of puberty on changes in leptin, testosterone, and insulin resistance in sedentary obese boy with considering possible crosstalk between leptin and insulin resistance. 58 sedentary obese boys (14.10 + 1.37 years) participated in this study. Tanner stage scales were used to measure puberty by self-reporting. Initially anthropometric characteristics and then, fasting serum’s glucose, insulin, leptin and testosterone, were measured. With increasing mature from TS2 to TS5, the increasing of testosterone, body mass and lean body mass and the reduction of body fat percentage were significantly (p≤0.05). but the changes in leptin and HOMA-IR were not significant. However, the decreased leptin after adjusting for BMI between TS3 and TS4 were significant (p≤0.05). During puberty, rapid growth in muscle tissue were associated with decreased body fat percent, serum leptin and insulin resistance. Among the possible reasons is a 15-fold increase in serum testosterone from TS2 to TS5. These changes reflect the cross talk between muscle and adipose tissue by hormonal mediators.

What is already known on this subject?

In previous studies, the role of leptin and insulin resistance in metabolic disease was investigated.

 

What this study adds?

In our study, it was shown that puberty can be effective in crosstalk between leptin, insulin and insulin resistance. However, it is suggested that in future studies, the role of exercise training during puberty be measured with these indicators.

Keywords

Main Subjects

References

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Journal of Exercise & Organ Cross Talk
Volume 1, Issue 1
June 2021
Pages 15-23

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History

  • Receive Date: 12 April 2021
  • Revise Date: 12 June 2021
  • Accept Date: 15 June 2021

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