Ackel-D’Elia, C., Carnier, J., Bueno Jr, C., Campos, R., Sanches, P., Clemente, A., . . . Dâmaso, A. (2014). Effects of different physical exercises on leptin concentration in obese adolescents. International journal of sports medicine, 35(2), 164-171. Doi: 10.1055/s-0033-1345128
Aguilar-Gomez, F., Bueno-Lozano, G., Leis, R., Aguilera, C., & Gil-Campos, M. (2020). Metabolic syndrome before puberty: Myth or reality? Current Opinion in Endocrine and Metabolic Research. Doi:
https://doi.org/10.1016/j.coemr.2020.06.006
Ahmed, M. L., Ong, K. K., & Dunger, D. B. (2009). Childhood obesity and the timing of puberty. Trends Endocrinol Metab, 20(5), 237-242. doi:10.1016/j.tem.2009.02.004.
Ahmed, M. L., Ong, K. K., Morrell, D. J., Cox, L., Drayer, N., Perry, L., .. Dunger, D. B. (1999). Longitudinal study of leptin concentrations during puberty: sex differences and relationship to changes in body composition. J Clin Endocrinol Metab, 84(3), 899-905. Doi:
https://doi.org/10.1210/jcem.84.3.5559
Amiel, S. A., Sherwin, R. S., Simonson, D. C., Lauritano, A. A., & Tamborlane, W. V. (1986). Impaired insulin action in puberty. A contributing factor to poor glycemic control in adolescents with diabetes. N Engl J Med, 315(4), 215-219. doi:10.1056/NEJM198607243150402
Argente, J., Barrios, V., Chowen, J., Sinha, M., (1997). Leptin plasma levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimia nervosa. J Pediatr, 131(6), 833-838. Doi:
https://doi.org/10.1016/S0022-3476(97)70029-5
Arslanian, S., Suprasongsin, C., Kalhan, S. C., Drash, A. L., Brna, R., (1998). Plasma leptin in children: relationship to puberty, gender, body composition, insulin sensitivity, and energy expenditure. Metabolism, 47(3), 309-312. Doi:
https://doi.org/10.1016/S0026-0495(98)90262-1
Biro, F. M., Greenspan, L. C., & Galvez, M. P. (2012). Puberty in girls of the 21st century. J Pediatr Adolesc Gynecol, 25(5), 289-294. doi:10.1016/j.jpag.2012.05.009
Blum, W. F., Englaro, P., Hanitsch, S., Juul, A., Hertel, N. T., Müller, J., . (1997). Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. Journal of Clinical Endocrinology & Metabolism, 82(9), 2904-2910. Doi:
https://doi.org/10.1210/jcem.82.9.4251
Boutcher, S., & Dunn, S. (2009). Factors that may impede the weight loss response to exercise‐based interventions. Obesity Reviews, 10(6), 671-680. Doi:
https://doi.org/10.1111/j.1467-789X.2009.00621.x
Bray, G. A. (1997). Obesity and reproduction. Human reproduction, 12(suppl 1), 26-32. Doi:
https://doi.org/10.1093/humrep/12.suppl_1.26
Burt Solorzano, C. M., & McCartney, C. R. (2010). Obesity and the pubertal transition in girls and boys. Reproduction, 140(3), 399-410. doi:10.1530/REP-10-0119
Buyken, A. E., Karaolis-Danckert, N., & Remer, T. (2009). Association of prepubertal body composition in healthy girls and boys with the timing of early and late pubertal markers. Am J Clin Nutr, 89(1), 221-230. doi:10.3945/ajcn.2008.26733
Caprio, S., Cline, G., Boulware, S., Permanente, C., Shulman, G. I., Sherwin, R. S., & Tamborlane, W. V. (1994). Effects of puberty and diabetes on metabolism of insulin-sensitive fuels. Am J Physiol, 266(6 Pt 1), E885-891. Doi:
https://doi.org/10.1152/ajpendo.1994.266.6.E885
Carnier, J., Sanches Pde, L., da Silva, P. L., de Piano, A., Tock, L., Campos, R. M., . . . Damaso, A. R. (2012). Obese adolescents with eating disorders: analysis of metabolic and inflammatory states. Physiol Behav, 105(2), 175-180. doi:10.1016/j.physbeh.2011.08.014
Conwell, L. S., Trost, S. G., Brown, W. J., & Batch, J. A. (2004). Indexes of insulin resistance and secretion in obese children and adolescents a validation study. Diabetes Care, 27(2), 314-319.
Damaso, A. R., de Piano, A., Sanches, P. L., Corgosinho, F., Tock, L., Oyama, L. M., . . . de Mello, M. T. (2011). Hyperleptinemia in obese adolescents deregulates neuropeptides during weight loss. Peptides, 32(7), 1384-1391. doi:10.1016/j.peptides.2011.04.025.
Dardeno, T. A., Chou, S. H., Moon, H.-S., Chamberland, J. P., Fiorenza, C. G., & Mantzoros, C. S. (2010). Leptin in human physiology and therapeutics. Frontiers in neuroendocrinology, 31(3), 377-393. Doi:
https://doi.org/10.1016/j.yfrne.2010.06.002
Ertl, T., Funke, S., Sarkany, I., Szabo, I., Rascher, W., Blum, W., & Sulyok, E. (1999). Postnatal changes of leptin levels in full-term and preterm neonates: their relation to intrauterine growth, gender and testosterone. Neonatology, 75(3), 167-176. Doi:
https://doi.org/10.1159/000014093
Fernandez-Real, J. M., & Ricart, W. (2003). Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev, 24(3), 278-301. Doi:
https://doi.org/10.1210/er.2002-0010
Gesteiro, E., Megía, A., Guadalupe-Grau, A., Fernandez-Veledo, S., Vendrell, J., & González-Gross, M. (2021). Early identification of metabolic syndrome risk: a review of reviews and proposal for defining pre-metabolic syndrome status. Nutrition, Metabolism and Cardiovascular Diseases. Doi:
https://doi.org/10.1016/j.numecd.2021.05.022
Goran, M. I., & Gower, B. A. (2001). Longitudinal study on pubertal insulin resistance. Diabetes, 50(11), 2444-2450. Doi:
https://doi.org/10.2337/diabetes.50.11.2444
Gueorguiev, M., Góth, M. I., & Korbonits, M. (2001). Leptin and puberty: a review. Pituitary, 4(1-2), 79-86. Doi:
https://doi.org/10.1023/A:1012943029127
Guercio, G., Rivarola, M. A., Chaler, E., Maceiras, M., & Belgorosky, A. (2003). Relationship between the growth hormone/insulin-like growth factor-I axis, insulin sensitivity, and adrenal androgens in normal prepubertal and pubertal girls. J Clin Endocrinol Metab, 88(3), 1389-1393. Doi:
https://doi.org/10.1210/jc.2002-020979
Gungor, N., Saad, R., Janosky, J., & Arslanian, S. (2004). Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. J Pediatr, 144(1), 47-55. Doi:
https://doi.org/10.1016/j.jpeds.2003.09.045
Han, J. C., Lawlor, D. A., & Kimm, S. (2010). Childhood obesity. The Lancet, 375(9727), 1737-1748. Doi:
https://doi.org/10.1016/S0140-6736(10)60171-7
Harwood, H. J., Jr. (2012). The adipocyte as an endocrine organ in the regulation of metabolic homeostasis. Neuropharmacology, 63(1), 57-75. doi:10.1016/j.neuropharm.2011.12.010
Hoffman, R. P., Vicini, P., Sivitz, W. I., & Cobelli, C. (2000). Pubertal adolescent male-female differences in insulin sensitivity and glucose effectiveness determined by the one compartment minimal model. Pediatr Res, 48(3), 384-388. doi:10.1203/00006450-200009000-00022
Horlick, M. B., Rosenbaum, M., Nicolson, M., Levine, L. S., Fedun, B., Wang, J., . . . Leibel, R. L. (2000). Effect of puberty on the relationship between circulating leptin and body composition. J Clin Endocrinol Metab, 85(7), 2509-2518. Doi:
https://doi.org/10.1210/jcem.85.7.6689
Huang, A., Reinehr, T., & Roth, C. L. (2020). Connections Between Obesity
and Puberty Invited by Manuel Tena-Sempere, Cordoba. Current Opinion in Endocrine and Metabolic Research. Doi:
https://doi.org/10.1016/j.coemr.2020.08.004
Jeffery, A. N., Metcalf, B. S., Hosking, J., Streeter, A. J., Voss, L. D., & Wilkin, T. J. (2012). Age before stage: insulin resistance rises before the onset of puberty: a 9-year longitudinal study (EarlyBird 26). Diabetes Care, 35(3), 536-541. doi:10.2337/dc11-1281
King, N. A., Caudwell, P., Hopkins, M., Byrne, N. M., Colley, R., Hills, A. P., . . . Blundell, J. E. (2007). Metabolic and behavioral compensatory responses to exercise interventions: barriers to weight loss. Obesity, 15(6), 1373-1383. Doi:
https://doi.org/10.1038/oby.2007.164
Labayen, I., Ortega, F. B., Moreno, L. A., Gonzalez-Gross, M., Jimenez-Pavon, D., Martinez-Gomez, D., . . . Ruiz, J. R. (2013). Physical activity attenuates the negative effect of low birth weight on leptin levels in European adolescents; the HELENA study. Nutr Metab Cardiovasc Dis, 23(4), 344-349. doi:10.1016/j.numecd.2011.12.004
Lee, S. J., Kim, S. H., Park, K. M., Lee, J. H., & Park, J.-W. (2016). Increased obesity resistance and insulin sensitivity in mice lacking the isocitrate dehydrogenase 2 gene. Free Radical Biology and Medicine, 99, 179-188. Doi:
https://doi.org/10.1016/j.freeradbiomed.2016.08.011
Mantzoros, C. S., Flier, J. S., & Rogol, A. D. (1997). A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. Journal of Clinical Endocrinology & Metabolism, 82(4), 1066-1070. Doi:
https://doi.org/10.1210/jcem.82.4.3878
Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., . . . Koniaris, A. (2011). Leptin in human physiology and pathophysiology. American Journal of Physiology-Endocrinology and Metabolism, 301(4), E567-E584. Doi:
https://doi.org/10.1152/ajpendo.00315.2011
Marroqui, L., Gonzalez, A., Neco, P., Caballero-Garrido, E., Vieira, E., Ripoll, C., . . . Quesada, I. (2012). Role of leptin in the pancreatic beta-cell: effects and signaling pathways. J Mol Endocrinol, 49(1), R9-17. doi:10.1530/JME-12-0025
Marshall, W. A., & Tanner, J. M. (1970). Variations in the pattern of pubertal changes in boys. Archives of disease in childhood, 45(239), 13-23. Doi:
http://dx.doi.org/10.1136/adc.45.239.13
Martinez-Gomez, D., Eisenmann, J. C., Gomez-Martinez, S., Veses, A., Romeo, J., Veiga, O. L., & Marcos, A. (2012). Associations of physical activity and fitness with adipocytokines in adolescents: the AFINOS Study. Nutr Metab Cardiovasc Dis, 22(3), 252-259. doi:10.1016/j.numecd.2010.07.010
Morales, A., Wasserfall, C., Brusko, T., Carter, C., Schatz, D., Silverstein, J., . . . Atkinson, M. (2004). Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes. Diabetes Care, 27(8), 2010-2014. Doi:
https://doi.org/10.2337/diacare.27.8.2010
Moran, A., Jacobs, D. R., Jr., Steinberger, J., Steffen, L. M., Pankow, J. S., Hong, C. P., & Sinaiko, A. R. (2008). Changes in insulin resistance and cardiovascular risk during adolescence: establishment of differential risk in males and females. Circulation, 117(18), 2361-2368. doi:10.1161/CIRCULATIONAHA.107.704569
Myers, M. G., Cowley, M. A., & Munzberg, H. (2008). Mechanisms of leptin action and leptin resistance. Annu Rev Physiol, 70, 537-556. doi:10.1146/annurev.physiol.70.113006.100707
Nasreddine, L., Naja, F., Tabet, M., Habbal, M.-Z., El-Aily, A., Haikal, C., . . . Hwalla, N. (2012). Obesity is associated with insulin resistance and components of the metabolic syndrome in Lebanese adolescents. Annals of human biology, 39(2), 122-128. Doi:
https://doi.org/10.3109/03014460.2012.655776
Nyambuya, T. M., Dludla, P. V., Mxinwa, V., & Nkambule, B. B. (2019). Obesity-induced inflammation and insulin resistance: A mini-review on T-cells. Metabolism open, 3, 100015. Doi:
https://doi.org/10.1016/j.metop.2019.100015
Odle, A. K., Akhter, N., Syed, M. M., Allensworth-James, M. L., Beneš, H., Melgar Castillo, A. I., . . . Childs, G. V. (2018). Leptin regulation of gonadotrope gonadotropin-releasing hormone receptors as a metabolic checkpoint and gateway to reproductive competence. Frontiers in endocrinology, 8, 367. Doi:
https://doi.org/10.3389/fendo.2017.00367
Oyama, L. M., Nascimento, C. M. O. d., Carnier, J., Piano, A. d., Tock, L., Sanches, P. d. L., . . . Dâmaso, A. R. (2010). The role of anorexigenic and orexigenic neuropeptides and peripheral signals on quartiles of weight loss in obese adolescents. Neuropeptides, 44(6), 467-474. Doi:
https://doi.org/10.1016/j.npep.2010.07.002
Park, J., Choi, H., Kim, I., Lee, H., Kang, J., & Song, J. (2012). Influence of serum leptin levels on future overweight risk in Korean children. Nutrition, Metabolism and Cardiovascular Diseases, 22(3), 260-268. Doi:
https://doi.org/10.1016/j.numecd.2010.08.010
Prado, W. L., Oyama, L. M., Lofrano-Prado, M. C., de Piano, A., Stella, S. G., Nascimento, C. M., . . . Damaso, A. R. (2011). Alterations in downstream mediators involved in central control of eating behavior in obese adolescents submitted to a multidisciplinary therapy. J Adolesc Health, 49(3), 300-305. doi:10.1016/j.jadohealth.2010.12.016
Qasim, A., Mehta, N. N., Tadesse, M. G., Wolfe, M. L., Rhodes, T., Girman, C., & Reilly, M. P. (2008). Adipokines, insulin resistance, and coronary artery calcification. Journal of the American College of Cardiology, 52(3), 231-236. Doi: 10.1016/j.jacc.2008.04.016
Rajpathak, S. N., Gunter, M. J., Wylie‐Rosett, J., Ho, G. Y., Kaplan, R. C., Muzumdar, R., . . . Strickler, H. D. (2009). The role of insulin‐like growth factor‐I and its binding proteins in glucose homeostasis and type 2 diabetes. Diabetes/metabolism research and reviews, 25(1), 3-12. Doi:
https://doi.org/10.1002/dmrr.919
Roemmich, J. N., Clark, P. A., Berr, S. S., Mai, V., Mantzoros, C. S., Flier,
J. S., . . . Rogol, A. D. (1998). Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. Am J Physiol, 275(3 Pt 1), E543-551. Doi:
https://doi.org/10.1152/ajpendo.1998.275.3.E543
Rogol, A. D. (2010). Sex steroids, growth hormone, leptin and the pubertal growth spurt. Endocr Dev, 17, 77-85. doi:10.1159/000262530
Roth, C. L., Kratz, M., Ralston, M. M., & Reinehr, T. (2011). Changes in adipose-derived inflammatory cytokines and chemokines after successful lifestyle intervention in obese children. Metabolism, 60(4), 445-452. doi:10.1016/j.metabol.2010.03.023
Rubin, D. A., McMurray, R. G., Harrell, J. S., Hackney, A. C., Thorpe, D. E., & Haqq, A. M. (2008). The association between insulin resistance and cytokines in adolescents: the role of weight status and exercise. Metabolism, 57(5), 683-690. doi:10.1016/j.metabol.2008.01.005
Rutters, F., Nieuwenhuizen, A. G., Verhoef, S. P., Lemmens, S. G., Vogels, N., & Westerterp-Plantenga, M. S. (2009). The relationship between leptin, gonadotropic hormones, and body composition during puberty in a Dutch children cohort. Eur J Endocrinol, 160(6), 973-978. doi:10.1530/EJE-08-0762.
Sengupta, P., Bhattacharya, K., & Dutta, S. (2019). Leptin and male repro duction. Asian Pacific Journal of Reproduction, 8(5), 220. Doi: 10.4103/2305-0500.268143
Sinaiko, A. R., Jacobs, D. R., Jr., Steinberger, J., Moran, A., Luepker, R., Rocchini, A. P., & Prineas, R. J. (2001). Insulin resistance syndrome in childhood: associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors. J Pediatr, 139(5), 700-707. doi:10.1067/mpd.2001.118535
Smith, S. R., & Ravussin, E. (2002). Emerging paradigms for understanding fatness and diabetes risk. Curr Diab Rep, 2(3), 223-230. Doi:
https://doi.org/10.1007/s11892-002-0087-1
Vatier, C., Gautier, J. F., & Vigouroux, C. (2012). Therapeutic use of recombinant methionyl human leptin. Biochimie, 94(10), 2116-2125. doi:10.1016/j.biochi.2012.03.013
Wabitsch, M., Blum, W. F., Muche, R., Braun, M., Hube, F., Rascher, W., ... & Hauner, H. (1997). Contribution of androgens to the gender difference in leptin production in obese children and adolescents. The Journal of clinical investigation, 100(4), 808-813.
https://www.jci.org/articles/view/119595
Wu, A. H. (2006). Tietz clinical guide to laboratory tests: Saunders/Elsevier St. Louis. eBook ISBN: 9781437719871