Brain-derived neurotrophic factor (BDNF) variation to aerobic exercise and aloe vera intake in women with type 2 diabetes

Document Type : Original Article


1 Assistant Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran

2 Master of Exercise Physiology, Department of Physical Education and Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran

3 Assistant Professor of Motor Behavior, Department of Physical Education and Sport Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran


This study aimed to investigate the interactive effect of aloe vera intake and eight weeks’ aerobic exercise on serum BDNF, glucose, and insulin levels in women with type 2 diabetes. In this experimental study, 32 women with type 2 diabetes were selected and randomly divided into four groups of control, supplement, exercise, exercise + supplement. The exercise program was performed 3 sessions per week for 8 weeks (40 min of exercise with 50-60% of heart rate reserve in the first four weeks and 60 min of exercise with 60-80% of heart rate reserve in the second four weeks). The supplement taking groups received 400 mg/kg of oral aloe Vera 3 days per week for 8 weeks. The data were analyzed using analysis of covariance (ANCOVA). A significant increase was observed in BDNF levels, insulin sensitivity of patients in the supplement, exercise, and exercise + supplement groups (p=0.001). The glucose and insulin levels, insulin resistance, BMI, and body fat percentage significantly decreased in the supplement, exercise, and exercise + supplement groups (p=0.001). It seems aloe Vera intake and aerobic exercise to have protective effects against development of type 2 diabetes complications in women.

What is already known on this subject?

Although the amount of BDNF (Key factor in brain-muscle cross talk) measures has increased with exercise training, to date, it remains an open question that BDNF change with aerobic exercise and aloe vera intake in women with type 2 diabetes.


What this study adds?

BDNF is produced and secreted by human skeletal muscles and other organs. BDNF has antidiabetic effect and associate with circulating anti-inflammatory cytokines in T2DM. This study show increase BDNF with aerobic exercise and aloe Vera intake in T2DM.


Main Subjects

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Volume 1, Issue 1
June 2021
Pages 1-7
  • Receive Date: 03 March 2021
  • Revise Date: 28 April 2021
  • Accept Date: 05 May 2021
  • First Publish Date: 11 May 2021