Vesnu Publications (Farzanegan Radandish) Journal of Exercise & Organ Cross Talk 2783-2074 6 2 2026 06 30 Smart running as a low-cost health-promoting strategy: The HamGhadam (step-for-good) workplace physical activity program at Gol-Gohar Sirjan club 116 130 243347 10.22122/jeoct.2026.573460.1189 EN Hosein Abedini Parizi Sports Science Committee, Gol Gohar cultural and sports club, Sirjan, Iran. 0000-0001-8978-2659 Ali Pahshabadi Department of Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran. 0000-0001-5950-4703 Aniss Khorasani PhD Candidate, Department of Sport Biomechanics, Faculty of Physical Education and Sport Science, Shahid Bahonar University of Kerman, Iran and Sports Scientific Committee, Gol Gohar cultural and Sports club, Sirjan, Iran. 0000-0001-8893-3822 Khatere Pour Jafarabadi Sports Director, Golgah Sports Cultural Club, Staff and Family and Sports Science Committee, Gol Gohar cultural and sports club, Sirjan, Iran. 0000-0002-3467-4455 Asqar Nikravesh HSE Manager, Gol Gohar Sirjan F.C. and Sports Science Committee, Gol Gohar cultural and sports club, Sirjan, Iran. 0000-0002-0006-3883 Amir Hossein Ahmadi Hekmatikar Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran 10600, Iran Sports Science Committee, Gol Gohar cultural and sports club, Sirjan, Iran. 0000-0003-1082-6335 Journal Article 2026 02 01 Physical inactivity is a major global determinant of non-communicable diseases, particularly in industrial and occupational environments where structural and environmental barriers limit regular engagement in physical activity. Although the health benefits of aerobic exercise are well established, less attention has been given to the physiological specificity of exercise intensity and its translation into feasible health promotion strategies in real world settings. Current evidence indicates that moderate intensity running (approximately 50–70% heart rate reserve, 46–63% VO₂max, or Borg RPE 12–14) induces coordinated multisystem signaling responses that support metabolic regulation and inflammatory balance. These responses include favorable modulation of myokines, adipokines, neurotrophic factors, and immunoregulatory mediators involved in metabolic homeostasis. Particular attention is given to the context dependent role of interleukin 6, highlighting the distinction between its transient exercises induced signaling effects and the chronic elevations associated with metabolic and inflammatory diseases. In addition to mechanistic insights, this review discusses translational considerations such as adherence, safety, and long term sustainability of moderate intensity running programs in occupational populations. The HamGhadam (Step for Good) initiative implemented by Gol Gohar Mining and Industrial Company is presented as a descriptive workplace case example illustrating how structured physical activity programs can be incorporated into corporate wellness initiatives. The manuscript does not claim empirical validation of the program’s effectiveness but highlights its potential as a practical model for workplace health promotion. Overall, smart running is framed as a biologically efficient and potentially scalable strategy that conceptually bridges molecular exercise biology with population level physical activity promotion. https://www.jeoct.com/article_243347_4f43e5649f5f9345313f65cacf298a13.pdf