TY - JOUR ID - 137295 TI - Muscle and serum antioxidant cross talk following curcumin and light resistance training during strenuous endurance training in male Wistar rats JO - Journal of Exercise & Organ Cross Talk JA - JEOCT LA - en SN - AU - Gorzi, Ali AU - Hosseini, Farzaneh AD - Department of Sport Sciences, Faculty of Humanities, University of Zanjan, Zanjan, Iran. AD - Ph.D Student in Sport Physiology, University of Kurdistan, Sanandaj, Iran. Y1 - 2021 PY - 2021 VL - 1 IS - 2 SP - 86 EP - 92 KW - resistance training KW - Endurance Training KW - curcumin KW - Antioxidant KW - Malondialdehyde KW - Muscle KW - Cross talk DO - https://doi.org/10.22034/JEOCT.2021.304496.1015 N2 - It has been proven that strenuous endurance training increases oxidative stress in body. This study investigated the effects of curcumin supplementation and light resistance training during 8 weeks of endurance training on muscle and serum antioxidant capacity and lipid peroxidation of male wistar rats. 44 male Wistar rats (weight: 254.31±17.72 g and age: 8 weeks) were randomly divided to 6 groups; Control (n=6, sham), Curcumin (n=6), Endurance (n=8), Endurance-curcumin (n=8), Endurance-Resistance (n=8), and Endurance-curcumin-resistance (n=8). Endurance training performed on rodent treadmill for 8 weeks and 5 sessions a week. The speed and duration of running were 10 m/min and 30 min at first week. The intensity and duration reached to the 35 m/min and 70 min up to the last week. Resistance training (8 weeks, 2 sessions / week) performed on vertical ladder (with 30-70% BW). The animals received curcumin supplement by sub peritoneal injection (8 weeks, 3 sessions / week, 30 mg/kg.Bw). Superoxide dismutase (SOD) enzyme activity was measured by Elisa kit and Malondialdehyde (MDA) was measured by the thiobarbituric acid reactive substances (TBARS).  The results of this study showed that strenuous endurance training (p<0.05) reduces the serum levels of SOD significantly, and caused a significant increase in the lipid peroxidation (MDA in muscle and serum). Curcumin supplementation and light resistance training could increase antioxidant enzymes activity (SOD) and decrease the MDA levels. The prolonged strenuous endurance training can induce oxidative stress and curcumin supplementation along with light resistance training could restore antioxidant enzymes activity and decrease the MDA levels. UR - https://www.jeoct.com/article_137295.html L1 - https://www.jeoct.com/article_137295_f9d95009ccc5d13baf6d0a56433d027d.pdf ER -