Journal of Exercise & Organ Cross Talk

Abstract The purpose of this research is to investigate the effect of High-intensity interval training and spirulina supplementation on the levels of Pannexin-1 and NLRP-1 proteins in hippocampal tissue in male rats with type 1 diabetes. In this experimental study, 30 Wistar rats, aged 10 weeks and weighing 180-260 grams, were randomly divided into 5 groups of 6 each: exercise group, supplement group, exercise + supplement group, control group, 5 healthy group. After inducing diabetes and implementing the protocol, hippocampal tissue from the rats was extracted, and the levels of PANNXIN-1 and NLRP-1 proteins were measured using the western blot method. Statistical analyses and data processing were conducted using SPSS version 26 software, with significance set at P≤0.05. The results showed a significant increase in Pannexin-1 and NLRP-1 proteins in diabetic rats (P<0.05). There was a noticeable decrease in protein expression after 6 weeks of rigorous intermittent exercise and spirulina supplements in the exercise, supplement, and exercise + supplement groups compared to the diabetic group. This reduction was mostly due to the combined effects of exercise and supplementation rather than either alone. Our research has verified the hypoglycemic effects of intense interval training and spirulina supplementation, along with their impact on reducing PANX-1 and NLRP-1 protein expression. Consequently, it appears that this form of physical activity and herbal supplement could significantly enhance the management of neurodegenerative disorders in individuals with type 1 diabetes.

Abstract The purpose of this study was to compare the effect of two methods of resistance training TRX and traditional resistance on the response of some indicators of muscle damage in soccer players. The present study was a semi-experimental; therefore, 36 participants with mean age of 19/36±1/4 were voluntarily selected and assigned to two groups of TRX and traditional resistance training. The training program for both groups consisted of several joint movements, these movements in 2 sets, with 8 repetitions in to isometric form, and the duration of muscle tension in each movement was 20 seconds. Both groups were evaluated by biochemical, physical and anthropometric measurements in two stages of pre-test and post-test. Data analysis was done using independent sample t-test and paired sample t-test with the significant level of 0.05 (p≤0.05). Serum creatine kinase levels showed a significant increase in traditional resistance training group 54.01% (p=0.001) and in the TRX training group 58.19% (p=0.003). Serum lactate dehydrogenase levels increased significantly as the result of traditional resistance training (p=0.033) while Aspartate aminotransferase did not show any significant changes from pre-test to post-test in the experimental groups. Moreover, the results of the present study showed that there was no significant difference in the changes observed in the indices of muscle damage between a traditional training and TRX training. Therefore, performing TRX or traditional training is not improving muscle injury during training.