Journal of Exercise & Organ Cross Talk

Abstract Cancer is the leading cause of death worldwide, with breast cancer posing a high risk for women. Immunotherapy has shown efficacy, and exercise is recognized for its role in cancer management. Combining both may enhance therapeutic outcomes. This study examined 30 female BALB/c mice (average weight: 17.76g), divided into five groups (n=6 each). After treadmill acclimation, they underwent two 6-week training protocols and a 4-week protocol post-cancer induction. Data analysis was performed using one-way ANOVA. The findings revealed significant differences in body weight among the EIEA and EIA groups compared to the control group. Similarly, in the heart weight analysis, both EIEA and EIA groups showed significant differences compared to the control (p<0.05). Notably, the combination of exercise and anti-PD-L1 antibody treatment effectively prevented weight loss in both body mass and heart weight. This protective effect may be attributed to the mitigation of cachexia, a common complication in cancer that leads to severe weight loss and muscle wasting. These results suggest that integrating physical activity with immunotherapy could serve as a potential strategy to counteract cancer-induced weight deterioration.

Abstract Cancer is now the leading global cause of death, with breast cancer being particularly deadly for women. This study investigates how physical activity combined with anti-PD-L1 antibody administration affects tumor weight and lifespan in mice with breast cancer. In this study, 30 male and female BALB/c mice, averaging 17.76 grams in weight, were selected and divided into the following groups: PCG (n=6), EIC (n=6), EIE (n=6), EIA (n=6), and EIE+A (n=6). Following an acclimation period on the treadmill, mice underwent two initial 4-week training protocols, followed by a 2-week protocol after cancer induction. A one-way analysis of variance (ANOVA) was performed to analyze the research variables. Statistical analysis showed no significant changes in survival time or tumor weight in the PCG, EIC, and EIE groups of breast cancer mice. However, the EIA and EIE+A groups demonstrated significant improvements in both survival and tumor weight reduction (p<0.05). The findings of this study suggest that the combination of physical activity and anti-PDL-1 antibody administration may lead to tumor apoptosis by enhancing positive immunological effects, which could be effective for better cancer management. However, it is recommended that future studies investigate the immunological and physiological effects of the tumor microenvironment with the combination of physical activity and anti-PDL-1 antibody administration.